Director
Dra Haydee Viola, Profesora UBA, Investigadora Principal CONICET
Contacto: hviola@fmed.uba.ar Tel: 5285-3180
Contacto: hviola@fmed.uba.ar Tel: 5285-3180
Equipo de Investigación
Lic. Pamela Lopes de Cunha, Becaria Doctoral CONICET.
Lic. Ramiro Tintorelli, Becario Doctoral CONICET.
Lic. Julieta Correa, Becaria Doctoral Agencia.
Bioq. Pablo Budriesi, Tesista de Maestria.
Lic. Ramiro Tintorelli, Becario Doctoral CONICET.
Lic. Julieta Correa, Becaria Doctoral Agencia.
Bioq. Pablo Budriesi, Tesista de Maestria.
Colaboradores
Dr. Jorge H Medina, Investigador Superior CONICET.
Dr Diego Moncada, Investigador Adjunto CONICET.
Dr Fabricio Ballarini, Investigador Asistente CONICET.
Dr Martin Giurfa, Exceptional-Class Professor, Research Center on Animal Cognition, CNRS - University Paul Sabatier - Toulouse, France.
Dr Diego Moncada, Investigador Adjunto CONICET.
Dr Fabricio Ballarini, Investigador Asistente CONICET.
Dr Martin Giurfa, Exceptional-Class Professor, Research Center on Animal Cognition, CNRS - University Paul Sabatier - Toulouse, France.
La formación de memorias de largo término bajo la hipótesis del "Etiquetado conductual"
En nuestro laboratorio estudiamos los mecanismos de formación de memorias de largo término (MLT). Se conoce que este mecanismo requiere de síntesis de proteínas. Sin embargo, hemos postulamos que son dos procesos los que ocurren en la formación de MLT: la síntesis proteica y el marcado de sitios específicos del aprendizaje donde se utilizan dichas proteínas.
Nuestros resultados avalan la existencia de estos dos procesos y nos permitieron postular la hipótesis del "Etiquetado conductual". Ella predice que aprendizajes débiles que no forman MLT, inducen las marcas del aprendizaje (pero no las proteínas) y utilizan proteínas provenientes de eventos que suceden en la cercanía temporal en poblaciones de neuronas compartidas entre los dos eventos.
Basados en este marco conceptual, estudiamos cómo una memoria débil puede establecerse en una MLT, gracias a la utilización y captura de las proteínas provenientes de la exploración espacial novedosa, de una experiencia estresante o de un reentrenamiento temporalmente asociados al aprendizaje débil. Registramos la memoria de las ratas en modelos de evitación inhibitoria, reconocimiento espacial, miedo contextual, aversión al gusto, entre otras. Estudiamos los mecanismos celulares involucrados en el proceso, utilizando técnicas de Western blot y de canulación intracerebral. También realizamos actividades en las escuelas para determinar si en los humanos se forman MLT mediante el proceso del "Etiquetado conductual".
2017-2020: (PICT 2016- 0172). "El aprendizaje espaciado y los mecanismos que optimizan la formación y la persistencia de memorias".
2018-2021: (UBACyT 20020170100501BA). "El aprendizaje espaciado y los mecanismos que optimizan la formación y la persistencia de memorias".
ERK1/2: a key cellular component for the formation, retrieval, reconsolidation, and persistence of memory.
Jorge H Medina and Haydee Viola
Front. Mol. Neurosci. Vol 11 Article 361, doi: 10.3389/fnmol.2018.00361, 2018.
Spatial object recognition memory formation under acute stress. Lopes da Cunha P, Villar ME, Ballarini F, Tintorelli R and Viola H. Hippocampus, doi: 10.1002/hipo.23037, 2018.
Exams at classroom have bidirectional effects on the long-term memory of an unrelated graphical task. Lopes da Cunha P, Ramirez Butavand D, Chisari LB, Ballarini F and Viola H. npj Science of Learning 3:19 ; doi:10.1038/s41539-018-0036-7, 2018
Novelty during a late post-acquisition time window attenuates the persistence of fear memory. Katche C, Tomaiuolo M, Dorman G, Medina JH and Viola H. Sci. Rep. 6, 35220; doi: 10.1038/srep35220, 2017.
Memory consolidation and expression of object recognition are susceptible to retroactive interference. Villar ME, Martinez MC, Lopes de Cunha P, Ballarini F and Viola H. Neurobiol Learn and Memory. pii: S1074-7427(16)30033-8. doi: 10.1016/j.nlm.2016.04.010. 2016.
Dorsal medial prefrontal cortex contributes to conditioned taste aversion memory consolidation and retrieval. Gonzalez MC; Villar ME; Igaz LM; Viola H and Medina JH. Neurobiol Learn and Memory, doi: 10.1016/j.nlm.2015.10.007, 2015.
Behavioral tagging; a translation of the synaptic tagging and capture hypothesis. Moncada D, Ballarini F and Viola H. Neural Plasticity, Review ID 650780. http://dx.doi.org/10.1155/2015/650780, 2105.
Evidence of maintenance tagging in the hippocampus for the persistence of long-lasting memory storage. Tomauiolo M, Katche C, Viola H and Medina JH. Neural Plasticity, Article ID 603672, http://dx.doi.org/10.1155/2015/603672, 2015.
Retroactive interference of object-in-context long-term memory: role of dorsal hippocampus and medial prefrontal cortex. Villar ME, Martinez MC, Ballarini F and Viola H. Hippocampus ;24(12):1482-92. doi: 10.1002/hipo.22328, 2014.
Memory in elementary school children is improved by an unrelated novel experience. Ballarini F, Martínez MC, Díaz Perez M, Moncada D, Viola H. Plos One Available online at http://dx.plos.org/10.1371/journal.pone.0066875, 2013.
Memory traces compete under regimes of limited Arc protein synthesis: implications for memory interference. Martínez MC, Alen N, Ballarini F, Moncada D, Viola H. Neurobiol Learn & Mem 98(2):165-73 http://dx.doi.org/10.1016/j.nlm., 2012.
Identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formation. Moncada D, Ballarini F, Martinez MC, Frey JU and Viola H. PNAS 108 (31): 12931-12936, 2011.
Behavioral Tagging is a general mechanism in memory formation. Ballarini F, Moncada D, MartinezMC, AlenN y Viola H. PNAS 106 (34):14599-14604, 2009.
The sedative effect of hesperidin is associated with a decrease in pERK1 /2 in the brain. M. Cecilia Martínez, Sebastián Fernández, Leonardo Loscalzo, Cristina Wasowski, Alejandro C. Paladini, Mariel Marder, Jorge Medina and Haydée Viola. Pharmacol Biochem Behav. 92(2):291-6, 2009.
PKM? inactivation induces spatial familiarity. Moncada D and Viola H. Learn Mem. 15(11): 810-4, 2008.
Induction of long-term memory by exposure to novelty requires protein synthesis: evidence for a Behavioral Tagging. Moncada D and Viola H. The Journal of Neuroscience 27 (28): 7476-7481, 2007.
Este artículo ha sido comentado en la sección de Journal Club de dicha revista en noviembre del 2007 con el titulo: "Hunting for synaptic tagging and capture in memory formation". A posteriori nosotros enviamos una e-letter al J Neurosci que figura on-line.
The tagging and capture hypothesis from synapse to memory.
Viola H, Ballarini F, Martinez MC and Moncada D. In Zafar U. Khan, E. Chris Muly, editors: Molecular Basis of Memory, Vol 122, PMBTS, UK: Academic Press, 2014, pp. 391-423. Elsevier PMBTS Book series "Molecular Biology of Memory" Co-editors: Zafar U. Khan and E. Chris Muly Prog Mol Biol Transl Sci.2014;122:391-423. doi:10.1016/B978-0-12-420170-5.00013-1.
The Behavioral Tagging Hypothesis and Its Implications for Long-Term Memory Formation. Book title: 'Synaptic Tagging and Capture: From Synapses to Behavior'
Moncada D, Ballarini F, Martinez MC and Viola H. ISBN 978-1-4939-1760-0 ISBN 978-1-4939-1761-7 (eBook) Ed:Sreedharan Sajikumar DOI 10.1007/978-1-4939-1761-7 Springer New York Heidelberg Dordrecht London, 2014, pp 231-261.
Spatial object recognition memory formation under acute stress. Lopes da Cunha P, Villar ME, Ballarini F, Tintorelli R and Viola H. Hippocampus, doi: 10.1002/hipo.23037, 2018.
Exams at classroom have bidirectional effects on the long-term memory of an unrelated graphical task. Lopes da Cunha P, Ramirez Butavand D, Chisari LB, Ballarini F and Viola H. npj Science of Learning 3:19 ; doi:10.1038/s41539-018-0036-7, 2018
Novelty during a late post-acquisition time window attenuates the persistence of fear memory. Katche C, Tomaiuolo M, Dorman G, Medina JH and Viola H. Sci. Rep. 6, 35220; doi: 10.1038/srep35220, 2017.
Memory consolidation and expression of object recognition are susceptible to retroactive interference. Villar ME, Martinez MC, Lopes de Cunha P, Ballarini F and Viola H. Neurobiol Learn and Memory. pii: S1074-7427(16)30033-8. doi: 10.1016/j.nlm.2016.04.010. 2016.
Dorsal medial prefrontal cortex contributes to conditioned taste aversion memory consolidation and retrieval. Gonzalez MC; Villar ME; Igaz LM; Viola H and Medina JH. Neurobiol Learn and Memory, doi: 10.1016/j.nlm.2015.10.007, 2015.
Behavioral tagging; a translation of the synaptic tagging and capture hypothesis. Moncada D, Ballarini F and Viola H. Neural Plasticity, Review ID 650780. http://dx.doi.org/10.1155/2015/650780, 2105.
Evidence of maintenance tagging in the hippocampus for the persistence of long-lasting memory storage. Tomauiolo M, Katche C, Viola H and Medina JH. Neural Plasticity, Article ID 603672, http://dx.doi.org/10.1155/2015/603672, 2015.
Retroactive interference of object-in-context long-term memory: role of dorsal hippocampus and medial prefrontal cortex. Villar ME, Martinez MC, Ballarini F and Viola H. Hippocampus ;24(12):1482-92. doi: 10.1002/hipo.22328, 2014.
Memory in elementary school children is improved by an unrelated novel experience. Ballarini F, Martínez MC, Díaz Perez M, Moncada D, Viola H. Plos One Available online at http://dx.plos.org/10.1371/journal.pone.0066875, 2013.
Memory traces compete under regimes of limited Arc protein synthesis: implications for memory interference. Martínez MC, Alen N, Ballarini F, Moncada D, Viola H. Neurobiol Learn & Mem 98(2):165-73 http://dx.doi.org/10.1016/j.nlm., 2012.
Identification of transmitter systems and learning tag molecules involved in behavioral tagging during memory formation. Moncada D, Ballarini F, Martinez MC, Frey JU and Viola H. PNAS 108 (31): 12931-12936, 2011.
Behavioral Tagging is a general mechanism in memory formation. Ballarini F, Moncada D, MartinezMC, AlenN y Viola H. PNAS 106 (34):14599-14604, 2009.
The sedative effect of hesperidin is associated with a decrease in pERK1 /2 in the brain. M. Cecilia Martínez, Sebastián Fernández, Leonardo Loscalzo, Cristina Wasowski, Alejandro C. Paladini, Mariel Marder, Jorge Medina and Haydée Viola. Pharmacol Biochem Behav. 92(2):291-6, 2009.
PKM? inactivation induces spatial familiarity. Moncada D and Viola H. Learn Mem. 15(11): 810-4, 2008.
Induction of long-term memory by exposure to novelty requires protein synthesis: evidence for a Behavioral Tagging. Moncada D and Viola H. The Journal of Neuroscience 27 (28): 7476-7481, 2007.
Este artículo ha sido comentado en la sección de Journal Club de dicha revista en noviembre del 2007 con el titulo: "Hunting for synaptic tagging and capture in memory formation". A posteriori nosotros enviamos una e-letter al J Neurosci que figura on-line.
CAPITULOS DE LIBRO
The tagging and capture hypothesis from synapse to memory.
Viola H, Ballarini F, Martinez MC and Moncada D. In Zafar U. Khan, E. Chris Muly, editors: Molecular Basis of Memory, Vol 122, PMBTS, UK: Academic Press, 2014, pp. 391-423. Elsevier PMBTS Book series "Molecular Biology of Memory" Co-editors: Zafar U. Khan and E. Chris Muly Prog Mol Biol Transl Sci.2014;122:391-423. doi:10.1016/B978-0-12-420170-5.00013-1.
The Behavioral Tagging Hypothesis and Its Implications for Long-Term Memory Formation. Book title: 'Synaptic Tagging and Capture: From Synapses to Behavior'
Moncada D, Ballarini F, Martinez MC and Viola H. ISBN 978-1-4939-1760-0 ISBN 978-1-4939-1761-7 (eBook) Ed:Sreedharan Sajikumar DOI 10.1007/978-1-4939-1761-7 Springer New York Heidelberg Dordrecht London, 2014, pp 231-261.
Grupo del Dra. Haydee Viola
